SCOPe 2.08: Domain d5tqgh_: 5tqg H:

Lineage for d5tqgh_ (5tqg H:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Coagulation factor VIIa [50550] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50551] (90 PDB entries)
   Uniprot P08709 213-466 ! Uniprot P08709 213-446

8. Domain d5tqgh_: 5tqg H: [329317]
   Other proteins in same PDB: d5tqgl_
   automated match to d1klih_
   complexed with 7ks, ca, gol, so4

Details for d5tqgh_

PDB Entry: 5tqg, 1.9 Å

PDB Description: factor viia in complex with the inhibitor (5r,11r)-11-[(1-amino-4- fluoroisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-7-(2,2- difluoroethoxy)-5,13-dimethyl-2,13-diazatricyclo[13.3.1.1~6, 10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione

PDB Compounds: (H:) Factor VIIa (Heavy Chain)

SCOPe Domain Sequences for d5tqgh_:

Sequence, based on SEQRES records:

>d5tqgh_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

Sequence, based on observed residues (ATOM records):

>d5tqgh_ b.47.1.2 (H:) Coagulation factor VIIa {Human (Homo sapiens) [TaxId: 9606]}
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrspniteymfcagysdgs
kdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmrsepr
pgvllrapfp

Timeline for d5tqgh_:

• d5tqgh_ first appeared in SCOPe 2.06
  
• d5tqgh_ appears in SCOPe 2.07