SCOPe 2.06: Domain d5l7ta1: 5l7t A:4-256

Lineage for d5l7ta1 (5l7t A:4-256)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein automated matches [190085] (51 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186828] (23 PDB entries)

8. Domain d5l7ta1: 5l7t A:4-256 [327438]
   Other proteins in same PDB: d5l7ta2
   automated match to d1ydef_
   complexed with 6qj, na, nad

Details for d5l7ta1

PDB Entry: 5l7t, 1.98 Å

PDB Description: 17beta-hydroxysteroid dehydrogenase 14 variant t205 in complex with a non-steroidal inhibitor.

PDB Compounds: (A:) 17-beta-hydroxysteroid dehydrogenase 14

SCOPe Domain Sequences for d5l7ta1:

Sequence; same for both SEQRES and ATOM records:

>d5l7ta1 c.2.1.2 (A:4-256) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gtryagkvvvvtgggrgigagivrafvnsgarvvicdkdesggraleqelpgavfilcdv
tqeddvktlvsetirrfgrldcvvnnaghhpppqrpeetsaqgfrqllelnllgtytltk
lalpylrksqgnvinisslvgaigqaqavpyvatkgavtamtkalaldespygvrvncis
pgniwtplweelaalmpdpratiregmlaqplgrmgqpaevgaaavflaseanfctgiel
lvtggaelgygck

Timeline for d5l7ta1:

• d5l7ta1 is new in SCOPe 2.06-stable
  
• d5l7ta1 appears in SCOPe 2.07
  
• d5l7ta1 appears in the current release, SCOPe 2.08