SCOPe 2.08: Domain d5wrnf1: 5wrn F:26-306

Lineage for d5wrnf1 (5wrn F:26-306)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (47 PDB entries)

8. Domain d5wrnf1: 5wrn F:26-306 [327249]
   Other proteins in same PDB: d5wrna2, d5wrnb2, d5wrnc2, d5wrnd2, d5wrne2, d5wrnf2
   automated match to d1hvya_
   complexed with dc

Details for d5wrnf1

PDB Entry: 5wrn, 2.39 Å

PDB Description: human thymidylate synthase complexed with dcmp

PDB Compounds: (F:) Thymidylate synthase

SCOPe Domain Sequences for d5wrnf1:

Sequence, based on SEQRES records:

>d5wrnf1 d.117.1.1 (F:26-306) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphpt

Sequence, based on observed residues (ATOM records):

>d5wrnf1 d.117.1.1 (F:26-306) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkdgtlsvfgmqaryslrdefpllttkrvfwkgvleellw
fikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyrdme
sdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnselsc
qlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlq
reprpfpklrilrkvekiddfkaedfqiegynphpt

Timeline for d5wrnf1:

• d5wrnf1 first appeared in SCOPe 2.06
  
• d5wrnf1 appears in SCOPe 2.07