SCOP 1.67: Domain d2shpb1: 2shp B:219-525

Lineage for d2shpb1 (2shp B:219-525)

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (3 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (5 proteins)
   has an extension to the beta-sheet of 3 antiparallel strands before strand 4

6. Protein Tyrosine phosphatase [52806] (7 species)

7. Species Human (Homo sapiens), shp-2 [TaxId:9606] [52810] (1 PDB entry)

8. Domain d2shpb1: 2shp B:219-525 [32684]
   Other proteins in same PDB: d2shpa2, d2shpa3, d2shpb2, d2shpb3
   contains tandem repeat of two SH2 domains in the N-terminal region
   complexed with cat; mutant

Details for d2shpb1

PDB Entry: 2shp, 2 Å

PDB Description: tyrosine phosphatase shp-2

SCOP Domain Sequences for d2shpb1:

Sequence, based on SEQRES records:

>d2shpb1 c.45.1.2 (B:219-525) Tyrosine phosphatase {Human (Homo sapiens), shp-2}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrsiymav
qhyietl

Sequence, based on observed residues (ATOM records):

>d2shpb1 c.45.1.2 (B:219-525) Tyrosine phosphatase {Human (Homo sapiens), shp-2}
trinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenknknryknilpfdht
rvvlhdsdyinaniimpkksyiatqgclqntvndfwrmvfqensrvivmttkevergksk
cvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhfrtwpdh
gvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiirekgvdc
didvpktiqmvrsqrsgmvqteaqyrsiymavqhyietl

Timeline for d2shpb1:

• d2shpb1 first appeared (with stable ids) in SCOP 1.55
  
• d2shpb1 appears in SCOP 1.65
  
• d2shpb1 appears in SCOP 1.69
  
• d2shpb1 appears in the current release, SCOPe 2.08