SCOPe 2.06: Domain d5trfa_: 5trf A:

Lineage for d5trfa_ (5trf A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.42: SWIB/MDM2 domain [47591] (1 superfamily)
   core: 4 helices: open bundle; capped by two small 3-stranded beta-sheets
   duplication: consists of two structural repeats

4. Superfamily a.42.1: SWIB/MDM2 domain [47592] (2 families)
   binds to the transactivation domain of human p53

5. Family a.42.1.1: SWIB/MDM2 domain [47593] (5 proteins)
   Pfam PF02201

6. Protein MDM2 [47594] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47596] (59 PDB entries)

8. Domain d5trfa_: 5trf A: [326171]
   automated match to d2lzga_
   complexed with 7hc, gol, so4

Details for d5trfa_

PDB Entry: 5trf, 2.1 Å

PDB Description: mdm2 in complex with sar405838

PDB Compounds: (A:) E3 ubiquitin-protein ligase Mdm2

SCOPe Domain Sequences for d5trfa_:

Sequence, based on SEQRES records:

>d5trfa_ a.42.1.1 (A:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
tdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlyde
kqqhivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

Sequence, based on observed residues (ATOM records):

>d5trfa_ a.42.1.1 (A:) MDM2 {Human (Homo sapiens) [TaxId: 9606]}
tdgavttsqipaseqetlvrpkplllkllksvgaqkdtytmkevlfylgqyimtkrlyqh
ivycsndllgdlfgvpsfsvkehrkiytmiyrnlvvvn

Timeline for d5trfa_:

• d5trfa_ is new in SCOPe 2.06-stable
  
• d5trfa_ appears in SCOPe 2.07
  
• d5trfa_ appears in the current release, SCOPe 2.08