SCOPe 2.08: Domain d5ktxa1: 5ktx A:1085-1196

Lineage for d5ktxa1 (5ktx A:1085-1196)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.1: Bromodomain [47371] (6 proteins)

6. Protein CREB-binding protein, CBP [74712] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [74713] (59 PDB entries)

8. Domain d5ktxa1: 5ktx A:1085-1196 [324752]
   Other proteins in same PDB: d5ktxa2
   automated match to d4nyxa_
   complexed with 6xh, dms, edo

Details for d5ktxa1

PDB Entry: 5ktx, 1.27 Å

PDB Description: crebbp bromodomain in complex with cpd59 ((s)-1-(3-((2-fluoro-4-(1- methyl-1h-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7- dihydro-1h-pyrazolo[4,3-c]pyridin-5(4h)-yl)ethanone)

PDB Compounds: (A:) creb-binding protein

SCOPe Domain Sequences for d5ktxa1:

Sequence; same for both SEQRES and ATOM records:

>d5ktxa1 a.29.2.1 (A:1085-1196) CREB-binding protein, CBP {Human (Homo sapiens) [TaxId: 9606]}
fkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlstikrkldt
gqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqal

Timeline for d5ktxa1:

• d5ktxa1 first appeared in SCOPe 2.06
  
• d5ktxa1 appears in SCOPe 2.07