SCOPe 2.06: Domain d5koqa_: 5koq A:

Lineage for d5koqa_ (5koq A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein Chymosin (synonym: renin) [50667] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50669] (76 PDB entries)

8. Domain d5koqa_: 5koq A: [324710]
   automated match to d1hrna_
   complexed with 6vr, nag, peg

Details for d5koqa_

PDB Entry: 5koq, 2.7 Å

PDB Description: discovery of tak-272: a novel, potent and orally active renin in- hibitor

PDB Compounds: (A:) renin

SCOPe Domain Sequences for d5koqa_:

Sequence, based on SEQRES records:

>d5koqa_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
nttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklf
dasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaef
dgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdpq
hyegnfhyinliktgvwqiqmkgvsvgsstllcedgclalvdtgasyisgstssieklme
algakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamd
ippptgptwalgatfirkfytefdrrnnrigfalar

Sequence, based on observed residues (ATOM records):

>d5koqa_ b.50.1.2 (A:) Chymosin (synonym: renin) {Human (Homo sapiens) [TaxId: 9606]}
nttssviltnymdtqyygeigigtppqtfkvvfdtgssnvwvpsskcsrlytacvyhklf
dasdsssykhngteltlrystgtvsgflsqdiitvggitvtqmfgevtempalpfmlaef
dgvvgmgfieqaigrvtpifdniisqgvlkedvfsfyynrdsensqslggqivlggsdpq
hyegnfhyinliktgvwqiqmkgvsvgstllcedgclalvdtgasyisgstssieklmea
lgakkrlfdyvvkcnegptlpdisfhlggkeytltsadyvfqesysskklctlaihamdi
ppptgptwalgatfirkfytefdrrnnrigfalar

Timeline for d5koqa_:

• d5koqa_ is new in SCOPe 2.06-stable
  
• d5koqa_ appears in SCOPe 2.07
  
• d5koqa_ appears in the current release, SCOPe 2.08