SCOPe 2.08: Domain d5lhba_: 5lhb A:

Lineage for d5lhba_ (5lhb A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.50: Macro domain-like [52948] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 6 strands, order 165243, strand 3 is antiparallel to the rest

4. Superfamily c.50.1: Macro domain-like [52949] (4 families)

5. Family c.50.1.3: Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain-like [310642] (2 proteins)
   Pfam PF05028
   Contains N- and C-terminal extensions to macrodomain, including Tyr clasp, discussed in PubMed 22609859

6. Protein Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain [310785] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [324080] (19 PDB entries)

8. Domain d5lhba_: 5lhb A: [324081]
   automated match to d4fc2d_
   complexed with 6wj, dms, so4

Details for d5lhba_

PDB Entry: 5lhb, 2.23 Å

PDB Description: polyadpribosyl glycosidase in complex with pdd00017262

PDB Compounds: (A:) Poly(ADP-ribose) glycohydrolase

SCOPe Domain Sequences for d5lhba_:

Sequence, based on SEQRES records:

>d5lhba_ c.50.1.3 (A:) Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
dkkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnk
hvkmpcseqnlypvedengertagsrweliqtallnkftrpqnlkdailkynvayskkwd
ftalidfwdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeq
iasllanaffctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfxyfrrvtaa
aptglvtftrqsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvts
aglvqeeirflinpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgs
erddwqrrcteivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgn
wgcgafggdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvy
klllryyneecrncstpgpdiklypfiyhavesc

Sequence, based on observed residues (ATOM records):

>d5lhba_ c.50.1.3 (A:) Poly(ADP-ribose) glycohydrolase (PARG) catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
dkkwlgtpieemrrmprcgirlpllrpsanhtvtirvdllragevpkpfpthykdlwdnk
hvkmpcseqnlypveertagsrweliqtallnkftrpqnlkdailkynvayskkwdftal
idfwdkvleeaeaqhlyqsilpdmvkialclpnictqpipllaaamnhsitmsqeqiasl
lanaffctfprrnakmkseyssypdinfnrlfegrssrkpeklktlfxyfrrvtaaaptg
lvtftrqsledfpewercekpltrlhvtyegtieengqgmlqvdfanrfvgggvtsaglv
qeeirflinpeliisrlftevldhnecliitgteqyseytgyaetyrwsrshedgserdd
wqrrcteivaidalhfrryldqfvpekmrrelnkaycgflrpgvssenlsavatgnwgcg
afggdarlkaliqilaaaaaerdvvyftfgdselmrdiysmhiflterkltvgdvyklll
ryyneecrncstpdiklypfiyhavesc

Timeline for d5lhba_:

• d5lhba_ first appeared in SCOPe 2.06
  
• d5lhba_ appears in SCOPe 2.07