SCOPe 2.08: Domain d5krsa1: 5krs A:57-207

Lineage for d5krsa1 (5krs A:57-207)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.55: Ribonuclease H-like motif [53066] (7 superfamilies)
   3 layers: a/b/a; mixed beta-sheet of 5 strands, order 32145; strand 2 is antiparallel to the rest

4. Superfamily c.55.3: Ribonuclease H-like [53098] (18 families)
   consists of one domain of this fold

5. Family c.55.3.2: Retroviral integrase, catalytic domain [53107] (2 proteins)
   Pfam PF00665

6. Protein Retroviral integrase, catalytic domain [53108] (5 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [53110] (74 PDB entries)

8. Domain d5krsa1: 5krs A:57-207 [323442]
   Other proteins in same PDB: d5krsa2
   automated match to d1biza_
   complexed with 6xi, dms

Details for d5krsa1

PDB Entry: 5krs, 1.7 Å

PDB Description: hiv-1 integrase catalytic core domain in complex with an allosteric inhibitor, 3-(1h-pyrrol-1-yl)-2-thiophenecarboxylic acid

PDB Compounds: (A:) integrase

SCOPe Domain Sequences for d5krsa1:

Sequence, based on SEQRES records:

>d5krsa1 c.55.3.2 (A:57-207) Retroviral integrase, catalytic domain {Human immunodeficiency virus type 1 [TaxId: 11676]}
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtd
ngsnftsttvkaacwwagikqefgipynpqsqgviesmnkelkkiigqvrdqaehlktav
qmavfihnkkrkggiggysagerivdiiatd

Sequence, based on observed residues (ATOM records):

>d5krsa1 c.55.3.2 (A:57-207) Retroviral integrase, catalytic domain {Human immunodeficiency virus type 1 [TaxId: 11676]}
spgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtd
ngsnftsttvkaacwwagikqefgipynpgviesmnkelkkiigqvrdqaehlktavqma
vfihnkkrkgggysagerivdiiatd

Timeline for d5krsa1:

• d5krsa1 first appeared in SCOPe 2.06
  
• d5krsa1 appears in SCOPe 2.07