SCOPe 2.08: Domain d5t3qa1: 5t3q A:1050-1350

Lineage for d5t3qa1 (5t3q A:1050-1350)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (67 PDB entries)

8. Domain d5t3qa1: 5t3q A:1050-1350 [323150]
   Other proteins in same PDB: d5t3qa2
   automated match to d1r0pa_
   complexed with 75h

Details for d5t3qa1

PDB Entry: 5t3q, 2 Å

PDB Description: crystal structure of the c-met kinase domain in complex with a pyrazolone inhibitor

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d5t3qa1:

Sequence, based on SEQRES records:

>d5t3qa1 d.144.1.7 (A:1050-1350) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
tvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcav
kslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfi
rnethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglardm
ydkeyysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvnt
fditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehy
v

Sequence, based on observed residues (ATOM records):

>d5t3qa1 d.144.1.7 (A:1050-1350) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
tvhidlsalnpelvqavqhvvigpsslivhfnevighfgcvyhgtlldndgkkihcavks
lnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirn
ethnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadlpvkwmale
slqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdply
evmlkcwhpkaemrpsfselvsrisaifstfigehyv

Timeline for d5t3qa1:

• d5t3qa1 first appeared in SCOPe 2.06
  
• d5t3qa1 appears in SCOPe 2.07