Lineage for d5ja3a_ (5ja3 A:)

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2903429Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 2903430Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) (S)
  5. 2903431Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)
  6. 2903517Protein Dihydrofolate reductase, prokaryotic type [53599] (9 species)
  7. 2903663Species Mycobacterium tuberculosis [TaxId:1773] [53602] (24 PDB entries)
  8. 2903698Domain d5ja3a_: 5ja3 A: [322633]
    automated match to d1df7a_
    complexed with ndp, u06

Details for d5ja3a_

PDB Entry: 5ja3 (more details), 1.81 Å

PDB Description: mycobacterium tuberculosis dihydrofolate reductase complexed with beta- nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1- yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (ucp1106)
PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d5ja3a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5ja3a_ c.71.1.1 (A:) Dihydrofolate reductase, prokaryotic type {Mycobacterium tuberculosis [TaxId: 1773]}
mvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpgr
rnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdiglp
reagdalapvldetwrgetgewrfsrsglryrlysyhrs

SCOPe Domain Coordinates for d5ja3a_:

Click to download the PDB-style file with coordinates for d5ja3a_.
(The format of our PDB-style files is described here.)

Timeline for d5ja3a_: