SCOPe 2.07: Domain d5ircd_: 5irc D:

Lineage for d5ircd_ (5irc D:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.8: G proteins [52592] (80 protein domains)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

6. Protein RhoA [52612] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52613] (33 PDB entries)
   Uniprot P61586 2-181

8. Domain d5ircd_: 5irc D: [321339]
   Other proteins in same PDB: d5irca1, d5irca2, d5ircb_
   automated match to d1cxza_
   complexed with cl, gdp, mg, mgf

Details for d5ircd_

PDB Entry: 5irc, 1.72 Å

PDB Description: p190a gap domain complex with rhoa

PDB Compounds: (D:) transforming protein rhoa

SCOPe Domain Sequences for d5ircd_:

Sequence, based on SEQRES records:

>d5ircd_ c.37.1.8 (D:) RhoA {Human (Homo sapiens) [TaxId: 9606]}
irkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdtagq
edydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrn
dehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalqa

Sequence, based on observed residues (ATOM records):

>d5ircd_ c.37.1.8 (D:) RhoA {Human (Homo sapiens) [TaxId: 9606]}
irkklvivgdgacgktcllivnvyvptvfenyvadievdgkqvelalwdtagqedydrlr
plsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrndehtrre
lakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalqa

Timeline for d5ircd_:

• d5ircd_ first appeared in SCOPe 2.06