SCOPe 2.06: Domain d5a8ya_: 5a8y A:

Lineage for d5a8ya_ (5a8y A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Elastase [50536] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50537] (12 PDB entries)

8. Domain d5a8ya_: 5a8y A: [320278]
   automated match to d1ppfe_
   complexed with 5ax, mes, mli, vbm

Details for d5a8ya_

PDB Entry: 5a8y, 1.9 Å

PDB Description: crystal structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

PDB Compounds: (A:) Neutrophil elastase

SCOPe Domain Sequences for d5a8ya_:

Sequence, based on SEQRES records:

>d5a8ya_ b.47.1.2 (A:) Elastase {Human (Homo sapiens) [TaxId: 9606]}
ivggrrarphawpfmvslqlrgghfcgatliapnfvmsaahcvanvnvravrvvlgahnl
srreptrqvfavqrifengydpvnllndivilqlngsatinanvqvaqlpaqgrrlgngv
qclamgwgllgrnrgiasvlqelnvtvvtslcrrsnvctlvrgrqagvcfgdsgsplvcn
glihgiasfvrggcasglypdafapvaqfvnwidsiiq

Sequence, based on observed residues (ATOM records):

>d5a8ya_ b.47.1.2 (A:) Elastase {Human (Homo sapiens) [TaxId: 9606]}
ivggrrarphawpfmvslqlrgghfcgatliapnfvmsaahcvanvnvravrvvlgahnl
srreptrqvfavqrifengydpvnllndivilqlngsatinanvqvaqlpaqgrrlgngv
qclamgwgllgrgiasvlqelnvtvvtslcrrsnvctlvrgrqagvcfgdsgsplvcngl
ihgiasfvrggcasglypdafapvaqfvnwidsiiq

Timeline for d5a8ya_:

• d5a8ya_ is new in SCOPe 2.06-stable
  
• d5a8ya_ appears in SCOPe 2.07
  
• d5a8ya_ appears in the current release, SCOPe 2.08