SCOPe 2.01: Domain d4q21a_: 4q21 A:

Lineage for d4q21a_ (4q21 A:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.8: G proteins [52592] (79 proteins)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

6. Protein cH-p21 Ras protein [52593] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52594] (84 PDB entries)
   Uniprot Q6P716

8. Domain d4q21a_: 4q21 A: [31978]
   complexed with gdp, mg

Details for d4q21a_

PDB Entry: 4q21, 2 Å

PDB Description: molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

PDB Compounds: (A:) c-h-ras p21 protein catalytic domain

SCOPe Domain Sequences for d4q21a_:

Sequence; same for both SEQRES and ATOM records:

>d4q21a_ c.37.1.8 (A:) cH-p21 Ras protein {Human (Homo sapiens) [TaxId: 9606]}
mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqhklr

Timeline for d4q21a_:

• d4q21a_ first appeared (with stable ids) in SCOP 1.55, called d4q21__
  
• d4q21a_ appears in SCOP 1.75
  
• d4q21a_ appears in SCOPe 2.02
  
• d4q21a_ appears in the current release, SCOPe 2.08