Lineage for d3tmkc_ (3tmk C:)

  1. Root: SCOPe 2.06
  2. 2089713Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2123292Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
    3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes
  4. 2123293Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families) (S)
    division into families based on beta-sheet topologies
  5. 2123294Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
    parallel beta-sheet of 5 strands, order 23145
  6. 2123759Protein Thymidylate kinase [52563] (4 species)
  7. 2123760Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52564] (3 PDB entries)
  8. 2123765Domain d3tmkc_: 3tmk C: [31922]
    complexed with t5a

Details for d3tmkc_

PDB Entry: 3tmk (more details), 2 Å

PDB Description: crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor tp5a at 2.0 a resolution: implications for catalysis and azt activation
PDB Compounds: (C:) thymidylate kinase

SCOPe Domain Sequences for d3tmkc_:

Sequence, based on SEQRES records: (download)

>d3tmkc_ c.37.1.1 (C:) Thymidylate kinase {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
mmgrgkliliegldrtgkttqcnilykklqpnckllkfperstrigglineyltddsfql
sdqaihllfsanrweivdkikkdllegknivmdryvysgvaysaakgtngmdldwclqpd
vgllkpdltlflstqdvdnnaeksgfgderyetvkfqekvkqtfmklldkeirkgdesit
ivdvtnkgiqevealiwqivepvlsthidhdkfsff

Sequence, based on observed residues (ATOM records): (download)

>d3tmkc_ c.37.1.1 (C:) Thymidylate kinase {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
mmgrgkliliegldrtgkttqcnilykklqpnckllkfperstrigglineyltddsfql
sdqaihllfsanrweivdkikkdllegknivmdryvysgvaysaakgtngmdldwclqpd
vgllkpdltlflstqdderyetvkfqekvkqtfmklldkeirkgdesitivdvtnkgiqe
vealiwqivepvlsthidhdkfsff

SCOPe Domain Coordinates for d3tmkc_:

Click to download the PDB-style file with coordinates for d3tmkc_.
(The format of our PDB-style files is described here.)

Timeline for d3tmkc_: