SCOPe 2.08: Domain d4zdaf_: 4zda F:

Lineage for d4zdaf_ (4zda F:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.2: Monomeric isocitrate dehydrogenase [82526] (2 proteins)
   the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion
   automatically mapped to Pfam PF03971

6. Protein automated matches [190493] (6 species)
   not a true protein

7. Species Mycobacterium smegmatis [TaxId:1772] [319123] (1 PDB entry)

8. Domain d4zdaf_: 4zda F: [319180]
   automated match to d2b0ta_
   complexed with ict, mn

Details for d4zdaf_

PDB Entry: 4zda, 2.8 Å

PDB Description: crystal structure of isocitrate dehydrogenase in complex with isocitrate and mn from m. smegmatis

PDB Compounds: (F:) Isocitrate dehydrogenase (NADP) Icd2

SCOPe Domain Sequences for d4zdaf_:

Sequence; same for both SEQRES and ATOM records:

>d4zdaf_ c.77.1.2 (F:) automated matches {Mycobacterium smegmatis [TaxId: 1772]}
ptiiytltdeapllatyaflpvvrkfaeaagidvktsdisvaarilaefgdhlteeqrvp
dnlgelgaltqdpsaniiklpnisasvpqllaaikelqgkgynvpdypanpktddekkik
dryakilgsavnpvlregnsdrrapkavkeyarkhphsmgewsqasrthvatmktgdfyh
geksmtldrdrrvkmvlktksgeeivlkpevkldagdiidsmymskkaliafyeeqieda
yktgvmfslhvkatmmkvshpivfghavkvfykdafakheklfdelgvnvnnglsdlydk
iealpasqreeiiedlhkchehrpelamvdsakgisnfhspsdvivdasmpamirlggkm
ygadgrtkdtkavnpestfsrmyqeminfckthgqfdpttmgtvpnvglmaqkaeeygsh
dktfeipedgvadivdidtgevlltqnveegdiwrmpivkdapirdwvklavtrarlsgm
pvvfwldterphevelrkkvkeylkdhdteglkiqimpqvwamrytlervvrgkdtiaat
gnilrdyltdlfpilelgtsakmlsivplmaggglyetgaggsapkhvhqlveenhlrwd
slgeflalgasledmgnktgnekakvlakaldtatgklleenkspsrrtgeldnrgsqfy
lslfwaqalaeqtedaelaerfkplakalaeqeeaivselnsvqgktvdiggyyypdpek
tsevmrpsktfnttl

Timeline for d4zdaf_:

• d4zdaf_ first appeared in SCOPe 2.06
  
• d4zdaf_ appears in SCOPe 2.07