SCOPe 2.07: Domain d5hf8a_: 5hf8 A:

Lineage for d5hf8a_ (5hf8 A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.69: alpha/beta-Hydrolases [53473] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 8 strands, order 12435678, strand 2 is antiparallel to the rest

4. Superfamily c.69.1: alpha/beta-Hydrolases [53474] (42 families)
   many members have left-handed crossover connection between strand 8 and additional strand 9

5. Family c.69.1.1: Acetylcholinesterase-like [53475] (6 proteins)
   automatically mapped to Pfam PF00135

6. Protein Acetylcholinesterase [53476] (6 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53480] (16 PDB entries)

8. Domain d5hf8a_: 5hf8 A: [318867]
   automated match to d2xupa_
   complexed with dep, edo, efs, fuc, nag, no3

Details for d5hf8a_

PDB Entry: 5hf8, 2.8 Å

PDB Description: crystal structure of human acetylcholinesterase in complex with paraoxon (alternative acyl loop conformation)

PDB Compounds: (A:) acetylcholinesterase

SCOPe Domain Sequences for d5hf8a_:

Sequence, based on SEQRES records:

>d5hf8a_ c.69.1.1 (A:) Acetylcholinesterase {Human (Homo sapiens) [TaxId: 9606]}
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvv
dgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagv
rvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqga
rvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanf
artgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsa

Sequence, based on observed residues (ATOM records):

>d5hf8a_ c.69.1.1 (A:) Acetylcholinesterase {Human (Homo sapiens) [TaxId: 9606]}
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcpndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdgdfls
dtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrvgvpq
vsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarvyayv
fehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfartgdp
neprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsa

Timeline for d5hf8a_:

• d5hf8a_ first appeared in SCOPe 2.06
  
• d5hf8a_ appears in the current release, SCOPe 2.08