SCOPe 2.06: Domain d1e2lb_: 1e2l B:

Lineage for d1e2lb_ (1e2l B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Thymidine kinase [52552] (4 species)
   contains insert all-alpha subdomain, res. 251-322

7. Species Herpes simplex virus type 1, different strains [TaxId:10298] [52553] (33 PDB entries)
   Uniprot P03176 46-375

8. Domain d1e2lb_: 1e2l B: [31873]
   complexed with so4, tmc; mutant

Details for d1e2lb_

PDB Entry: 1e2l, 2.4 Å

PDB Description: kinetics and crystal structure of the wild-type and the engineered y101f mutant of herpes simplex virus type 1 thymidine kinase interacting with (north)-methanocarba-thymidine

PDB Compounds: (B:) Thymidine kinase

SCOPe Domain Sequences for d1e2lb_:

Sequence, based on SEQRES records:

>d1e2lb_ c.37.1.1 (B:) Thymidine kinase {Herpes simplex virus type 1, different strains [TaxId: 10298]}
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianifttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhp
iaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpge
rldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphig
dtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlts
gmvqthvttpgsipticdlartfaremge

Sequence, based on observed residues (ATOM records):

>d1e2lb_ c.37.1.1 (B:) Thymidine kinase {Herpes simplex virus type 1, different strains [TaxId: 10298]}
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianifttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsppaltlifdrhpiaal
lcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrldlamlaai
rrvygllantvrylqcggswredwgqlsgpqsnagprphigdtlftlfrapellapngdl
ynvfawaldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdl
artfaremge

Timeline for d1e2lb_:

• d1e2lb_ first appeared (with stable ids) in SCOP 1.55
  
• d1e2lb_ appears in SCOPe 2.05
  
• d1e2lb_ appears in SCOPe 2.07
  
• d1e2lb_ appears in the current release, SCOPe 2.08