SCOPe 2.05: Domain d1ki2b_: 1ki2 B:

Lineage for d1ki2b_ (1ki2 B:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (25 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Thymidine kinase [52552] (3 species)
   contains insert all-alpha subdomain, res. 251-322

7. Species Herpes simplex virus type 1, different strains [TaxId:10298] [52553] (33 PDB entries)
   Uniprot P03176 46-375

8. Domain d1ki2b_: 1ki2 B: [31871]
   protein/DNA complex; complexed with ga2, so4

Details for d1ki2b_

PDB Entry: 1ki2, 2.2 Å

PDB Description: crystal structure of thymidine kinase from herpes simplex virus type i complexed with ganciclovir

PDB Compounds: (B:) Thymidine kinase

SCOPe Domain Sequences for d1ki2b_:

Sequence, based on SEQRES records:

>d1ki2b_ c.37.1.1 (B:) Thymidine kinase {Herpes simplex virus type 1, different strains [TaxId: 10298]}
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhp
iaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpge
rldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphig
dtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlts
gmvqthvttpgsipticdlartfaremgea

Sequence, based on observed residues (ATOM records):

>d1ki2b_ c.37.1.1 (B:) Thymidine kinase {Herpes simplex virus type 1, different strains [TaxId: 10298]}
mptllrvyidgphgmgkttttqllvalgdivyvpepmtywrvlgasetianiyttqhrld
qgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhpiaa
llcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpgerld
lamlaairrvygllantvrylqcggswredwgqlsnagprphigdtlftlfrapellapn
gdlynvfawaldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipti
cdlartfaremgea

Timeline for d1ki2b_:

• d1ki2b_ first appeared (with stable ids) in SCOP 1.55
  
• d1ki2b_ appears in SCOPe 2.04
  
• d1ki2b_ appears in SCOPe 2.06
  
• d1ki2b_ appears in the current release, SCOPe 2.08