Lineage for d1dtwb1 (1dtw B:17-204)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108430Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (5 protein domains)
    parent family to TK and PFOR
    heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
    automatically mapped to Pfam PF02779
  6. 2108434Protein Branched-chain alpha-keto acid dehydrogenase, Pyr module [88742] (2 species)
  7. 2108435Species Human (Homo sapiens) [TaxId:9606] [88743] (23 PDB entries)
    Uniprot P21953 52-392
  8. 2108458Domain d1dtwb1: 1dtw B:17-204 [31828]
    Other proteins in same PDB: d1dtwa_, d1dtwb2
    complexed with k, mg, tdp

Details for d1dtwb1

PDB Entry: 1dtw (more details), 2.7 Å

PDB Description: human branched-chain alpha-keto acid dehydrogenase
PDB Compounds: (B:) branched-chain alpha-keto acid dehydrogenase beta subunit

SCOPe Domain Sequences for d1dtwb1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1dtwb1 c.36.1.7 (B:17-204) Branched-chain alpha-keto acid dehydrogenase, Pyr module {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1dtwb1:

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Timeline for d1dtwb1:

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