SCOPe 2.08: Domain d5aa9a_: 5aa9 A:

Lineage for d5aa9a_ (5aa9 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d5aa9a_: 5aa9 A: [318163]
   automated match to d4foda_
   complexed with 5p8; mutant

Details for d5aa9a_

PDB Entry: 5aa9, 1.93 Å

PDB Description: structure of l1198f mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo- 10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).

PDB Compounds: (A:) ALK tyrosine kinase receptor

SCOPe Domain Sequences for d5aa9a_:

Sequence, based on SEQRES records:

>d5aa9a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsplqvavktl
pevcseqdeldflmealiiskfnhqnivrcigvslqslprfillefmaggdlksflretr
prpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfg
mardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympyps
ksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdv
intalpieyg

Sequence, based on observed residues (ATOM records):

>d5aa9a_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgafgevyegqvplqvavktlpevcseqd
eldflmealiiskfnhqnivrcigvslqslprfillefmaggdlksflretrprpsqpss
lamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrg
gcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsgg
rmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg

Timeline for d5aa9a_:

• d5aa9a_ first appeared in SCOPe 2.06
  
• d5aa9a_ appears in SCOPe 2.07