SCOP 1.63: Domain d1tkaa2: 1tka A:338-534

Lineage for d1tkaa2 (1tka A:338-534)

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (4 families)
   both pyridine (Pyr)- and pyrophosphate (PP)-binding modules have this fold
   conserved core consists of two Pyr and two PP-modules and binds two coenzyme molecules

5. Family c.36.1.2: TK-like THDP-binding domains [52528] (2 proteins)
   different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

6. Protein Transketolase (TK), PP and Pyr modules [52529] (2 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52530] (7 PDB entries)

8. Domain d1tkaa2: 1tka A:338-534 [31816]
   Other proteins in same PDB: d1tkaa3, d1tkab3

Details for d1tkaa2

PDB Entry: 1tka, 2.7 Å

PDB Description: specificity of coenzyme binding in thiamin diphosphate dependent enzymes: crystal structures of yeast transketolase in complex with analogs of thiamin diphosphate

SCOP Domain Sequences for d1tkaa2:

Sequence; same for both SEQRES and ATOM records:

>d1tkaa2 c.36.1.2 (A:338-534) Transketolase (TK), PP and Pyr modules {Baker's yeast (Saccharomyces cerevisiae)}
lpanwesklptytakdsavatrklsetvledvynqlpeliggsadltpsnltrwkealdf
qppssgsgnysgryirygirehamgaimngisafganykpyggtflnfvsyaagavrlsa
lsghpviwvathdsigvgedgpthqpietlahfrslpniqvwrpadgnevsaayknsles
khtpsiialsrqnlpql

Timeline for d1tkaa2:

• d1tkaa2 first appeared (with stable ids) in SCOP 1.55
  
• d1tkaa2 appears in SCOP 1.61
  
• d1tkaa2 appears in SCOP 1.65
  
• d1tkaa2 appears in the current release, SCOPe 2.08