Lineage for d1tkaa1 (1tka A:3-337)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108664Family c.36.1.10: TK-like PP module [88760] (3 protein domains)
    different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
  6. 2108683Protein Transketolase (TK), PP module [88761] (4 species)
  7. 2108684Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88762] (7 PDB entries)
  8. 2108693Domain d1tkaa1: 1tka A:3-337 [31815]
    Other proteins in same PDB: d1tkaa2, d1tkaa3, d1tkab2, d1tkab3
    complexed with ca, n3t

Details for d1tkaa1

PDB Entry: 1tka (more details), 2.7 Å

PDB Description: specificity of coenzyme binding in thiamin diphosphate dependent enzymes: crystal structures of yeast transketolase in complex with analogs of thiamin diphosphate
PDB Compounds: (A:) transketolase

SCOPe Domain Sequences for d1tkaa1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1tkaa1 c.36.1.10 (A:3-337) Transketolase (TK), PP module {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}

SCOPe Domain Coordinates for d1tkaa1:

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Timeline for d1tkaa1: