SCOPe 2.08: Domain d5aaaa_: 5aaa A:

Lineage for d5aaaa_ (5aaa A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d5aaaa_: 5aaa A: [318078]
   automated match to d4foda_
   complexed with vgh; mutant

Details for d5aaaa_

PDB Entry: 5aaa, 1.73 Å

PDB Description: structure of l1198f mutant human anaplastic lymphoma kinase in complex with crizotinib

PDB Compounds: (A:) ALK tyrosine kinase receptor

SCOPe Domain Sequences for d5aaaa_:

Sequence, based on SEQRES records:

>d5aaaa_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsplqvavktl
pevcseqdeldflmealiiskfnhqnivrcigvslqslprfillefmaggdlksflretr
prpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfg
mardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympyps
ksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdv
intalpiey

Sequence, based on observed residues (ATOM records):

>d5aaaa_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
npnycfagktssisdlkevprknitlirglghgafgevyegqvplqvavktlpevcseqd
eldflmealiiskfnhqnivrcigvslqslprfillefmaggdlksflretrprpsqpss
lamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgmardiyrg
gcamlpvkwmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsgg
rmdppkncpgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpiey

Timeline for d5aaaa_:

• d5aaaa_ first appeared in SCOPe 2.06
  
• d5aaaa_ appears in SCOPe 2.07