SCOPe 2.08: Domain d5dlxa1: 5dlx A:44-166

Lineage for d5dlxa1 (5dlx A:44-166)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.0: automated matches [191428] (1 protein)
   not a true family

6. Protein automated matches [190615] (15 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187641] (1052 PDB entries)

8. Domain d5dlxa1: 5dlx A:44-166 [317902]
   Other proteins in same PDB: d5dlxa2
   automated match to d4hbwa_
   complexed with 5d2

Details for d5dlxa1

PDB Entry: 5dlx, 1.9 Å

PDB Description: first domain of human bromodomain brd4 in complex with inhibitor n-{3- [4-(3-chlorophenyl)piperazin-1-yl]propyl}-1-{3-methyl-[1,2, 4]triazolo[4,3-b]pyridazin-6-yl}piperidine-4-carboxamide

PDB Compounds: (A:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d5dlxa1:

Sequence; same for both SEQRES and ATOM records:

>d5dlxa1 a.29.2.0 (A:44-166) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiikt
pmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkine
lpt

Timeline for d5dlxa1:

• d5dlxa1 first appeared in SCOPe 2.06
  
• d5dlxa1 appears in SCOPe 2.07