Class c: Alpha and beta proteins (a/b) [51349] (134 folds) |
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily) 3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465 |
Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules |
Family c.36.1.9: Pyruvate oxidase and decarboxylase PP module [88749] (7 proteins) the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology |
Protein Pyruvate decarboxylase [88750] (3 species) |
Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88752] (2 PDB entries) |
Domain d1pvdb3: 1pvd B:361-556 [31780] Other proteins in same PDB: d1pvda1, d1pvda2, d1pvdb1, d1pvdb2 complexed with mg, tpp |
PDB Entry: 1pvd (more details), 2.3 Å
SCOP Domain Sequences for d1pvdb3:
Sequence; same for both SEQRES and ATOM records: (download)
>d1pvdb3 c.36.1.9 (B:361-556) Pyruvate decarboxylase {Baker's yeast (Saccharomyces cerevisiae)} astplkqewmwnqlgnflqegdvviaetgtsafginqttfpnntygisqvlwgsigfttg atlgaafaaeeidpkkrvilfigdgslqltvqeistmirwglkpylfvlnndgytiekli hgpkaqyneiqgwdhlsllptfgakdyethrvattgewdkltqdksfndnskirmieiml pvfdapqnlvkqaklt
Timeline for d1pvdb3: