SCOPe 2.08: Domain d5hlpb_: 5hlp B:

Lineage for d5hlpb_ (5hlp B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Glycogen synthase kinase-3 beta (Gsk3b) [69823] (2 species)
   CMGC group; GSK3 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69824] (57 PDB entries)
   Uniprot P49841 35-383 ! Uniprot P49841 35-384

8. Domain d5hlpb_: 5hlp B: [317788]
   automated match to d1j1bb_
   complexed with 65a

Details for d5hlpb_

PDB Entry: 5hlp, 2.45 Å

PDB Description: x-ray crystal structure of gsk3b in complex with brd3937

PDB Compounds: (B:) Glycogen synthase kinase-3 beta

SCOPe Domain Sequences for d5hlpb_:

Sequence, based on SEQRES records:

>d5hlpb_ d.144.1.7 (B:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
relqimrkldhcnivrlryffyssgekkdevylnlvldyvpetvyrvarhysrakqtlpv
iyvklymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvs
yicsryyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgt
ptreqiremnpnytefkfpqikahpwtkvfrprtppeaialcsrlleytptarltpleac
ahsffdelrdpnvklpngrdtpalfnfttqelssnpplatilipphar

Sequence, based on observed residues (ATOM records):

>d5hlpb_ d.144.1.7 (B:) Glycogen synthase kinase-3 beta (Gsk3b) {Human (Homo sapiens) [TaxId: 9606]}
kvttvvatpgqgpdrpqevsytdtkvigngsfgvvyqaklcdsgelvaikkvlqdkrfkn
relqimrkldhcnivrlryffyssevylnlvldyvpetvyrvarhysrakqtlpviyvkl
ymyqlfrslayihsfgichrdikpqnllldpdtavlklcdfgsakqlvrgepnvsyicsr
yyrapelifgatdytssidvwsagcvlaelllgqpifpgdsgvdqlveiikvlgtptreq
iremnpnpqikahpwtkvfrprtppeaialcsrlleytptarltpleacahsffdelrdp
nvklpngrdtpalfnfttqelssnpplatilipphar

Timeline for d5hlpb_:

• d5hlpb_ first appeared in SCOPe 2.06
  
• d5hlpb_ appears in SCOPe 2.07