Lineage for d1pvda2 (1pvd A:2-181)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2108258Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 2108259Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. 2108260Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 protein domains)
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
    automatically mapped to Pfam PF02776
  6. 2108366Protein Pyruvate decarboxylase [88725] (3 species)
  7. 2108367Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88727] (2 PDB entries)
  8. 2108368Domain d1pvda2: 1pvd A:2-181 [31777]
    Other proteins in same PDB: d1pvda1, d1pvda3, d1pvdb1, d1pvdb3
    complexed with mg, tpp

Details for d1pvda2

PDB Entry: 1pvd (more details), 2.3 Å

PDB Description: crystal structure of the thiamin diphosphate dependent enzyme pyruvate decarboxylase from the yeast saccharomyces cerevisiae at 2.3 angstroms resolution
PDB Compounds: (A:) pyruvate decarboxylase

SCOPe Domain Sequences for d1pvda2:

Sequence, based on SEQRES records: (download)

>d1pvda2 c.36.1.5 (A:2-181) Pyruvate decarboxylase {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}

Sequence, based on observed residues (ATOM records): (download)

>d1pvda2 c.36.1.5 (A:2-181) Pyruvate decarboxylase {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}

SCOPe Domain Coordinates for d1pvda2:

Click to download the PDB-style file with coordinates for d1pvda2.
(The format of our PDB-style files is described here.)

Timeline for d1pvda2: