SCOPe 2.05: Domain d1dhsa_: 1dhs A:

Lineage for d1dhsa_ (1dhs A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.1: Deoxyhypusine synthase, DHS [52468] (1 protein)
   automatically mapped to Pfam PF01916

6. Protein Deoxyhypusine synthase, DHS [52469] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52470] (4 PDB entries)
   Uniprot P49366

8. Domain d1dhsa_: 1dhs A: [31727]
   complexed with nad

Details for d1dhsa_

PDB Entry: 1dhs, 2.2 Å

PDB Description: crystal structure of the nad complex of human deoxyhypusine synthase

PDB Compounds: (A:) deoxyhypusine synthase

SCOPe Domain Sequences for d1dhsa_:

Sequence, based on SEQRES records:

>d1dhsa_ c.31.1.1 (A:) Deoxyhypusine synthase, DHS {Human (Homo sapiens) [TaxId: 9606]}
apagalaavlkhsstlppestqvrgydfnrgvnyralleafgttgfqatnfgravqqvna
miekkleplsqdedqhadltqsrrpltsctiflgytsnlissgiretirylvqhnmvdvl
vttaggveedlikclaptylgefslrgkelrenginrignllvpnenyckfedwlmpild
qmvmeqntegvkwtpskmiarlgkeinnpesvyywaqknhipvfspaltdgslgdmiffh
syknpglvldivedlrlintqaifakctgmiilgggvvkhhiananlmrngadyavyint
aqefdgsdsgarpdeavswgkirvdaqpvkvyadaslvfpllvaetfaqkmdafmhekne
d

Sequence, based on observed residues (ATOM records):

>d1dhsa_ c.31.1.1 (A:) Deoxyhypusine synthase, DHS {Human (Homo sapiens) [TaxId: 9606]}
apagalaavlkhsstlppestqvrgydfnrgvnyralleafgttgfqatnfgravqqvna
miekklepltsctiflgytsnlissgiretirylvqhnmvdvlvttaggveedlikclap
tylgefslrgkelrenginrignllvpnenyckfedwlmpildqmvmeqntegvkwtpsk
miarlgkeinnpesvyywaqknhipvfspaltdgslgdmiffhsyknpglvldivedlrl
intqaifakctgmiilgggvvkhhiananlmrngadyavyintaqefdgsdsgarpdeav
swgkirvdaqpvkvyadaslvfpllvaetfaqkmdafmhekned

Timeline for d1dhsa_:

• d1dhsa_ first appeared (with stable ids) in SCOP 1.55, called d1dhs__
  
• d1dhsa_ appears in SCOPe 2.04
  
• d1dhsa_ appears in SCOPe 2.06
  
• d1dhsa_ appears in the current release, SCOPe 2.08