SCOPe 2.06: Domain d5in9a_: 5in9 A:

Lineage for d5in9a_ (5in9 A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.1: Heat shock protein 90, HSP90, N-terminal domain [55875] (2 proteins)

6. Protein HSP90 [55876] (3 species)

7. Species Dog (Canis familiaris) [TaxId:9615] [103225] (26 PDB entries)
   Uniprot P41148 76-285; Endoplasmin, GRP94

8. Domain d5in9a_: 5in9 A: [317000]
   automated match to d2exla_
   complexed with 6c0, gol, pge

Details for d5in9a_

PDB Entry: 5in9, 2.6 Å

PDB Description: crystal structure of grp94 bound to methyl 3-chloro-2-(2-(1-((5- chlorofuran-2-yl)methyl)-1h-imidazol-2-yl)ethyl)-4,6- dihydroxybenzoate, an inhibitor based on the bnim and radamide scaffolds.

PDB Compounds: (A:) Endoplasmin

SCOPe Domain Sequences for d5in9a_:

Sequence, based on SEQRES records:

>d5in9a_ d.122.1.1 (A:) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqstselig
qfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlke
easdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn

Sequence, based on observed residues (ATOM records):

>d5in9a_ d.122.1.1 (A:) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteastseligqfgvg
fysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlkeeasdy
leldtiknlvkkysqfinfpiyvwsskktvwdwelmn

Timeline for d5in9a_:

• d5in9a_ is new in SCOPe 2.06-stable
  
• d5in9a_ appears in SCOPe 2.07
  
• d5in9a_ appears in the current release, SCOPe 2.08