SCOPe 2.06: Domain d5iexa_: 5iex A:

Lineage for d5iexa_ (5iex A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (374 PDB entries)
   Uniprot P24941

8. Domain d5iexa_: 5iex A: [316368]
   automated match to d1h00a_
   complexed with 6af

Details for d5iexa_

PDB Entry: 5iex, 2.03 Å

PDB Description: crystal structure of (r,s)-s-{4-[(5-bromo-4-{[(2r,3r)-2-hydroxy-1- methylpropyl]oxy}- pyrimidin-2-yl)amino]phenyl}-s- cyclopropylsulfoximide bound to cdk2

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d5iexa_:

Sequence, based on SEQRES records:

>d5iexa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d5iexa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirlgvpstaireisllkelnhpnivk
lldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlh
rdlkpqnllintegaikladfglarafgvpvtlwyrapeillgckyystavdiwslgcif
aemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvp
pldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d5iexa_:

• d5iexa_ is new in SCOPe 2.06-stable
  
• d5iexa_ appears in SCOPe 2.07
  
• d5iexa_ appears in the current release, SCOPe 2.08