SCOPe 2.08: Domain d5ibmb3: 5ibm B:219-524

Lineage for d5ibmb3 (5ibm B:219-524)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423

4. Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families)
   share with the family I the common active site structure with a circularly permuted topology

5. Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 proteins)
   has an extension to the beta-sheet of 3 antiparallel strands before strand 4

6. Protein automated matches [190252] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187034] (47 PDB entries)

8. Domain d5ibmb3: 5ibm B:219-524 [315470]
   Other proteins in same PDB: d5ibma1, d5ibma2, d5ibmb1, d5ibmb2
   automated match to d2shpa1
   mutant

Details for d5ibmb3

PDB Entry: 5ibm, 2.18 Å

PDB Description: structure of s502p, a cancer-associated mutation of the oncogenic phosphatase shp2

PDB Compounds: (B:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d5ibmb3:

Sequence, based on SEQRES records:

>d5ibmb3 c.45.1.2 (B:219-524) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpfdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrpgmvqteaqyrfiymav
qhyiet

Sequence, based on observed residues (ATOM records):

>d5ibmb3 c.45.1.2 (B:219-524) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenknknryknilpfdht
rvvlhdgdppvsdyinaniimpepkksyiatqgclqntvndfwrmvfqensrvivmttke
vergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyh
frtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidii
rekgvdcdidvpktiqmvrsqrpgmvqteaqyrfiymavqhyiet

Timeline for d5ibmb3:

• d5ibmb3 first appeared in SCOPe 2.06
  
• d5ibmb3 appears in SCOPe 2.07