Lineage for d5i6va3 (5i6v A:219-525)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2454571Fold c.45: (Phosphotyrosine protein) phosphatases II [52798] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 4 strands, order 1423
  4. 2454572Superfamily c.45.1: (Phosphotyrosine protein) phosphatases II [52799] (6 families) (S)
    share with the family I the common active site structure with a circularly permuted topology
  5. 2454684Family c.45.1.2: Higher-molecular-weight phosphotyrosine protein phosphatases [52805] (7 proteins)
    has an extension to the beta-sheet of 3 antiparallel strands before strand 4
  6. 2454892Protein automated matches [190252] (5 species)
    not a true protein
  7. 2454893Species Human (Homo sapiens) [TaxId:9606] [187034] (47 PDB entries)
  8. 2454911Domain d5i6va3: 5i6v A:219-525 [315462]
    Other proteins in same PDB: d5i6va1, d5i6va2, d5i6vb1, d5i6vb2
    automated match to d2shpa1
    complexed with gol; mutant

Details for d5i6va3

PDB Entry: 5i6v (more details), 1.87 Å

PDB Description: structure of f285s, a cancer-associated mutation of the oncogenic phosphatase shp2
PDB Compounds: (A:) Tyrosine-protein phosphatase non-receptor type 11

SCOPe Domain Sequences for d5i6va3:

Sequence, based on SEQRES records: (download)

>d5i6va3 c.45.1.2 (A:219-525) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelsklaettdkvkqgfweefetlqqqeckllysrkegqrqenknknr
yknilpsdhtrvvlhdgdpnepvsdyinaniimpefetkcnnskpkksyiatqgclqntv
ndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytl
relklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvh
csagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymav
qhyietl

Sequence, based on observed residues (ATOM records): (download)

>d5i6va3 c.45.1.2 (A:219-525) automated matches {Human (Homo sapiens) [TaxId: 9606]}
trinaaeiesrvrelskgfweefetlqqqeckllysrkegqrqenknknryknilpsdht
rvvlhdgdpnepvsdyinaniimpekksyiatqgclqntvndfwrmvfqensrvivmttk
evergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqy
hfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidi
irekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietl

SCOPe Domain Coordinates for d5i6va3:

Click to download the PDB-style file with coordinates for d5i6va3.
(The format of our PDB-style files is described here.)

Timeline for d5i6va3: