SCOPe 2.08: Domain d5iisa_: 5iis A:

Lineage for d5iisa_ (5iis A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Proto-oncogene serine/threonine-protein kinase Pim-1 [118133] (1 species)
   OPK group(?); PIM subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118134] (118 PDB entries)
   Uniprot P11309 33-305 ! Uniprot P11309 32-308

8. Domain d5iisa_: 5iis A: [315444]
   automated match to d4k18a_
   complexed with 6cb, peg

Details for d5iisa_

PDB Entry: 5iis, 2.1 Å

PDB Description: design, synthesis and structure activity relationship of potent pan- pim kinase inhibitors derived from the pyridyl-amide scaffold

PDB Compounds: (A:) Serine/threonine-protein kinase pim-1

SCOPe Domain Sequences for d5iisa_:

Sequence; same for both SEQRES and ATOM records:

>d5iisa_ d.144.1.7 (A:) Proto-oncogene serine/threonine-protein kinase Pim-1 {Human (Homo sapiens) [TaxId: 9606]}
eplesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevv
llkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqv
leavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppe
wiryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwcl
alrpsdrptfeeiqnhpwmqdvllpqetaeihlh

Timeline for d5iisa_:

• d5iisa_ first appeared in SCOPe 2.06
  
• d5iisa_ appears in SCOPe 2.07