SCOPe 2.08: Domain d5anda_: 5and A:

Lineage for d5anda_ (5and A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d5anda_: 5and A: [315215]
   automated match to d1okva_
   complexed with 5je

Details for d5anda_

PDB Entry: 5and, 2.3 Å

PDB Description: crystal structure of cdk2 in complex with 2-imidazol-1-yl-1h- benzimidazole processed with the crystaldirect automated mounting and cryo-cooling technology

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d5anda_:

Sequence, based on SEQRES records:

>d5anda_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
enfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnhp
nivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchsh
rvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyys
tavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfp
kwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvp

Sequence, based on observed residues (ATOM records):

>d5anda_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
enfqkvekigegtygvvykarnkltgevvalkkipstaireisllkelnhpnivklldvi
htenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdlkp
qnllintegaikladfglarafvtlwyrapeillgckyystavdiwslgcifaemvtrra
lfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppldedgrs
llsqmlhydpnkrisakaalahpffqdvtkpvp

Timeline for d5anda_:

• d5anda_ first appeared in SCOPe 2.06
  
• d5anda_ appears in SCOPe 2.07