Lineage for d5hg8a_ (5hg8 A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2543502Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
    PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase
  7. 2543503Species Human (Homo sapiens) [TaxId:9606] [82796] (109 PDB entries)
    Uniprot P00533 702-1018
  8. 2543506Domain d5hg8a_: 5hg8 A: [314935]
    automated match to d3ikaa_
    complexed with 634, gol, so4

Details for d5hg8a_

PDB Entry: 5hg8 (more details), 1.42 Å

PDB Description: egfr (l858r, t790m, v948r) in complex with n-[3-({2-[(1-methyl-1h- pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]prop- 2-enamide
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d5hg8a_:

Sequence; same for both SEQRES and ATOM records: (download)

>d5hg8a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankei
ldeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggkvpik
wmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppic
tidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyr

SCOPe Domain Coordinates for d5hg8a_:

Click to download the PDB-style file with coordinates for d5hg8a_.
(The format of our PDB-style files is described here.)

Timeline for d5hg8a_: