SCOPe 2.08: Domain d5hcvc_: 5hcv C:

Lineage for d5hcvc_ (5hcv C:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein automated matches [190059] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187214] (171 PDB entries)

8. Domain d5hcvc_: 5hcv C: [314689]
   automated match to d2a3ia_
   complexed with 60r, cl

Details for d5hcvc_

PDB Entry: 5hcv, 2.5 Å

PDB Description: identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

PDB Compounds: (C:) Mineralocorticoid receptor

SCOPe Domain Sequences for d5hcvc_:

Sequence, based on SEQRES records:

>d5hcvc_ a.123.1.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpgfknlpled
qitliqyswmslssfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqisl
qfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtkcpnnsgqs
wqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnak
plyfh

Sequence, based on observed residues (ATOM records):

>d5hcvc_ a.123.1.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pvmvleniepeivyagypdtaenllstlnrlagkqmiqvvkwakvlpgfknlpledqitl
iqyswmslssfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqislqfvr
lqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvswqrfyqltkllds
mhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvnakplyfh

Timeline for d5hcvc_:

• d5hcvc_ first appeared in SCOPe 2.06
  
• d5hcvc_ appears in SCOPe 2.07