SCOPe 2.08: Domain d5eyca_: 5eyc A:

Lineage for d5eyca_ (5eyc A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (67 PDB entries)

8. Domain d5eyca_: 5eyc A: [314524]
   automated match to d1r0pa_
   complexed with 5sz

Details for d5eyca_

PDB Entry: 5eyc, 1.8 Å

PDB Description: crystal structure of c-met in complex with naphthyridinone inhibitor 5

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d5eyca_:

Sequence, based on SEQRES records:

>d5eyca_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
idlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavksl
nritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirne
thnptvkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmydk
eyysvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfdi
tvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfi

Sequence, based on observed residues (ATOM records):

>d5eyca_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
idlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtllkihcavkslnritd
igevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethnpt
vkdligfglqvakgmkylaskkfvhrdlaarncmldekftvkvadfglardmydkeyysv
hnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyll
qgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfi

Timeline for d5eyca_:

• d5eyca_ first appeared in SCOPe 2.06
  
• d5eyca_ appears in SCOPe 2.07