SCOPe 2.06: Domain d5f3gd_: 5f3g D:

Lineage for d5f3gd_ (5f3g D:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.82: Double-stranded beta-helix [51181] (7 superfamilies)
   one turn of helix is made by two pairs of antiparallel strands linked with short turns
   has appearance of a sandwich of distinct architecture and jelly-roll topology

4. Superfamily b.82.2: Clavaminate synthase-like [51197] (16 families)
   Iron and ketoglutarate-dependent enzymes; elaborated version of this common fold

5. Family b.82.2.14: Histone demethylase core [254153] (4 proteins)
   Jumonji domain; Pfam PF02375 (JmjN) and Pfam PF02373 (JmjC); relationship to FIH1 (b.82.2.6) described in PubMed 16983801

6. Protein JMJD2A core [254342] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [254775] (41 PDB entries)

8. Domain d5f3gd_: 5f3g D: [313865]
   automated match to d4v2wb_
   complexed with 5ul, cl, dms, zn

Details for d5f3gd_

PDB Entry: 5f3g, 2.5 Å

PDB Description: crystal structure of human kdm4a in complex with compound 53a

PDB Compounds: (D:) lysine-specific demethylase 4a

SCOPe Domain Sequences for d5f3gd_:

Sequence, based on SEQRES records:

>d5f3gd_ b.82.2.14 (D:) JMJD2A core {Human (Homo sapiens) [TaxId: 9606]}
sarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlvipap
iqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknltfnpp
iygadvngtlyekhvdewnigrlrtildlvekesgitiegvntpylyfgmwktsfawhte
dmdlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplml
kkygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscrk
dmvkismdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

Sequence, based on observed residues (ATOM records):

>d5f3gd_ b.82.2.14 (D:) JMJD2A core {Human (Homo sapiens) [TaxId: 9606]}
sarimtfyptmeefrnfsryiayiesqgahraglakvvppkewkprasyddiddlvipap
iqqlvtgqsglftqyniqkkamtvrefrkiansdkyctprysefeelerkywknltfnpp
iygadvngtlyekhvdewnigrlrtildlvekesgitivntpylyfgmwktsfawhtedm
dlysinylhfgepkswysvppehgkrlerlakgffpgsaqsceaflrhkmtlisplmlkk
ygipfdkvtqeagefmitfpygyhagfnhgfncaestnfatrrwieygkqavlcscmvki
smdvfvrkfqperyklwkagkdntvidhtlptpeaaefl

Timeline for d5f3gd_:

• d5f3gd_ is new in SCOPe 2.06-stable
  
• d5f3gd_ appears in SCOPe 2.07
  
• d5f3gd_ appears in the current release, SCOPe 2.08