SCOPe 2.08: Domain d5ezxa_: 5ezx A:

Lineage for d5ezxa_ (5ezx A:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d5ezxa_: 5ezx A: [313860]
   automated match to d1fkna_
   complexed with 5t5, dms, na

Details for d5ezxa_

PDB Entry: 5ezx, 1.9 Å

PDB Description: crystal structure of bace-1 in complex with {(1r,2r)-2-[(r)-2-amino-4- (4-difluoromethoxy-phenyl)-4,5-dihydro-oxazol-4-yl]-cyclopropyl}-(5- chloro-pyridin-3-yl)-methanone

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d5ezxa_:

Sequence, based on SEQRES records:

>d5ezxa_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmi
iggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlr
lpkkvfeaavasikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqs
fritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfa
vsachvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d5ezxa_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
rgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgasvggsmiiggidhslytg
slwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaava
sikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqyl
rpvsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaave
gpfvtldmedcgyn

Timeline for d5ezxa_:

• d5ezxa_ first appeared in SCOPe 2.06
  
• d5ezxa_ appears in SCOPe 2.07