Lineage for d5egua_ (5egu A:)

  1. Root: SCOPe 2.08
  2. 2685877Class a: All alpha proteins [46456] (290 folds)
  3. 2706693Fold a.29: Bromodomain-like [47363] (15 superfamilies)
    4 helices; bundle; minor mirror variant of up-and-down topology
  4. 2706694Superfamily a.29.2: Bromodomain [47370] (2 families) (S)
  5. 2706927Family a.29.2.0: automated matches [191428] (1 protein)
    not a true family
  6. 2706928Protein automated matches [190615] (15 species)
    not a true protein
  7. 2706959Species Human (Homo sapiens) [TaxId:9606] [187641] (1052 PDB entries)
  8. 2708169Domain d5egua_: 5egu A: [313658]
    Other proteins in same PDB: d5egud2
    automated match to d4hbwa_
    complexed with 5nq, edo

Details for d5egua_

PDB Entry: 5egu (more details), 2.21 Å

PDB Description: first domain of human bromodomain brd4 in complex with inhibitor 3- butyl-8-(6-butyl-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2- ylsulfanylmethyl)-7-ethyl-3,7-dihydropurine-2,6-dione
PDB Compounds: (A:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d5egua_:

Sequence, based on SEQRES records: (download)

>d5egua_ a.29.2.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiikt
pmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkine
lpte

Sequence, based on observed residues (ATOM records): (download)

>d5egua_ a.29.2.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nppppetsnpnrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiiktpmd
mgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkinelpt
e

SCOPe Domain Coordinates for d5egua_:

Click to download the PDB-style file with coordinates for d5egua_.
(The format of our PDB-style files is described here.)

Timeline for d5egua_: