SCOPe 2.08: Domain d5dh5b1: 5dh5 B:439-759

Lineage for d5dh5b1 (5dh5 B:439-759)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (9 families)

5. Family a.211.1.0: automated matches [191566] (1 protein)
   not a true family

6. Protein automated matches [190983] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188676] (139 PDB entries)

8. Domain d5dh5b1: 5dh5 B:439-759 [313576]
   Other proteins in same PDB: d5dh5b2
   automated match to d4ajmd_
   complexed with 5ay, mg, zn

Details for d5dh5b1

PDB Entry: 5dh5, 2 Å

PDB Description: pde10 complexed with n-[(1-methylpyrazol-4-yl)methyl]-5-[[(1s,2s)-2- (2-pyridyl)cyclopropyl]methoxy]pyrazolo[1,5-a]pyrimidin-7-amine

PDB Compounds: (B:) cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

SCOPe Domain Sequences for d5dh5b1:

Sequence; same for both SEQRES and ATOM records:

>d5dh5b1 a.211.1.0 (B:439-759) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sictseewqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfelekl
crfimsvkknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhr
gfsnsylqkfdhplaalyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirk
aiiatdlalyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtklt
andiyaefwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilppt
epllkacrdnlsqwekvirge

Timeline for d5dh5b1:

• d5dh5b1 first appeared in SCOPe 2.06
  
• d5dh5b1 appears in SCOPe 2.07