SCOPe 2.08: Domain d4yc8a_: 4yc8 A:

Lineage for d4yc8a_ (4yc8 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d4yc8a_: 4yc8 A: [312081]
   automated match to d2f4ja_
   complexed with 4b7, edo, mes

Details for d4yc8a_

PDB Entry: 4yc8, 2.9 Å

PDB Description: c-helix-out binding of dasatinib analog to c-abl kinase

PDB Compounds: (A:) Tyrosine-protein kinase ABL1

SCOPe Domain Sequences for d4yc8a_:

Sequence, based on SEQRES records:

>d4yc8a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke
ikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissame
ylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapesla
ynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelm
racwqwnpsdrpsfaeihqafetmfqess

Sequence, based on observed residues (ATOM records):

>d4yc8a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dkwemertditmkhklevyegvwkkysltvavktlmeveeflkeaavmkeikhpnlvqll
gvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissameylekknfihr
dlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkfsiksdv
wafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracwqwnpsd
rpsfaeihqafetmfqess

Timeline for d4yc8a_:

• d4yc8a_ first appeared in SCOPe 2.06
  
• d4yc8a_ appears in SCOPe 2.07