SCOPe 2.08: Domain d4y1pa_: 4y1p A:

Lineage for d4y1pa_ (4y1p A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (4 proteins)
   the active site is between the two identical subunits

6. Protein automated matches [190072] (22 species)
   not a true protein

7. Species Sulfolobus acidocaldarius [TaxId:330779] [311781] (1 PDB entry)

8. Domain d4y1pa_: 4y1p A: [311782]
   automated match to d1wpwa_
   complexed with ipm, mg, so4

Details for d4y1pa_

PDB Entry: 4y1p, 2.2 Å

PDB Description: crystal structure of 3-isopropylmalate dehydrogenase (saci_0600) from sulfolobus acidocaldarius complex with 3-isopropylmalate and mg2+

PDB Compounds: (A:) 3-isopropylmalate dehydrogenase

SCOPe Domain Sequences for d4y1pa_:

Sequence, based on SEQRES records:

>d4y1pa_ c.77.1.1 (A:) automated matches {Sulfolobus acidocaldarius [TaxId: 330779]}
gfvvaliqgdgigpevvsksktilarlnekfslpieyieveagdttknkfgdalpkdslr
viekadmilkgpvgetaadvvvklrlmydlyanlrpakslpglenkfgdvdilvvrente
dlykglehvisdgvtvgikvitraastriaqvalnqalrrkkkvvcvhksnvmritdglf
aescrnvlkgkveysemyvdaaaanlvrnpqafdvivtentygdilsdeagqiagslgis
psanigdrkslfepvhgaafdiagknianptafllsvgmmldrmqelsgdirynnaaksl
rdaiysvysegkyltpdvggssttdemisairskig

Sequence, based on observed residues (ATOM records):

>d4y1pa_ c.77.1.1 (A:) automated matches {Sulfolobus acidocaldarius [TaxId: 330779]}
gfvvaliqgdgigpevvsksktilarlnekfslpieyieveagdttknkfgdalpkdslr
viekadmilkgpvgetaadvvvklrlmydlyanlrpakslpglnkfgdvdilvvrented
lykglehvisdgvtvgikvitraastriaqvalnqalrrkkkvvcvhksnvmritdglfa
escrnvlkgkveysemyvdaaaanlvrnpqafdvivtentygdilsdeagqiagslgisp
sanigdrkslfepvhgaafdiagknianptafllsvgmmldrmqelsgdirynnaakslr
daiysvysegkyltpdvggssttdemisairskig

Timeline for d4y1pa_:

• d4y1pa_ first appeared in SCOPe 2.06
  
• d4y1pa_ appears in SCOPe 2.07