SCOPe 2.08: Domain d5eqpa_: 5eqp A:

Lineage for d5eqpa_ (5eqp A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.8: Choline kinase [90040] (2 proteins)
   Pfam PF02958

6. Protein Choline kinase [90041] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [311002] (13 PDB entries)

8. Domain d5eqpa_: 5eqp A: [310523]
   automated match to d2i7qa_
   complexed with 5r9

Details for d5eqpa_

PDB Entry: 5eqp, 2.35 Å

PDB Description: crystal structure of choline kinase alpha-1 bound by 6-[(4-methyl-1,4- diazepan-1-yl)methyl]quinoline (compound 37)

PDB Compounds: (A:) choline kinase alpha

SCOPe Domain Sequences for d5eqpa_:

Sequence, based on SEQRES records:

>d5eqpa_ d.144.1.8 (A:) Choline kinase {Human (Homo sapiens) [TaxId: 9606]}
qpeprtrrraylwckeflpgawrglredefhisvirgglsnmlfqcslpdttatlgdepr
kvllrlygailqmrscnkegseqaqkenefqgaeamvlesvmfailaerslgpklygifp
qgrleqfipsrrldteelslpdisaeiaekmatfhgmkmpfnkepkwlfgtmekylkevl
rikfteesrikklhkllsynlplelenlrsllestpspvvfchndcqegnilllegrens
ekqklmlidfeyssynyrgfdignhfcewmydysyekypffranirkyptkkqqlhfiss
ylpafqndfenlsteeksiikeemllevnrfalashflwglwsivqakissiefgymdya
qarfdayfhqkrklgv

Sequence, based on observed residues (ATOM records):

>d5eqpa_ d.144.1.8 (A:) Choline kinase {Human (Homo sapiens) [TaxId: 9606]}
qpeprtrrraylwckeflpgawrglredefhisvirgglsnmlfqcslpdttatlgdepr
kvllrlygaeamvlesvmfailaerslgpklygifpqgrleqfipsrrldteelslpdis
aeiaekmatfhgmkmpfnkepkwlfgtmekylkevlrikfteesrikklhkllsynlple
lenlrsllestpspvvfchndcqegnilllegrensekqklmlidfeyssynyrgfdign
hfcewmydysyekypffranirkyptkkqqlhfissylpafqndfenlsteeksiikeem
llevnrfalashflwglwsivqakissiefgymdyaqarfdayfhqkrklgv

Timeline for d5eqpa_:

• d5eqpa_ first appeared in SCOPe 2.06
  
• d5eqpa_ appears in SCOPe 2.07