SCOPe 2.08: Domain d4y6qb_: 4y6q B:

Lineage for d4y6qb_ (4y6q B:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
   silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

6. Protein Sirt2 histone deacetylase [63987] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63988] (23 PDB entries)

8. Domain d4y6qb_: 4y6q B: [310101]
   automated match to d1j8fc_
   complexed with omr, zn

Details for d4y6qb_

PDB Entry: 4y6q, 1.9 Å

PDB Description: human sirt2 in complex with 2-o-myristoyl-adp-ribose

PDB Compounds: (B:) nad-dependent protein deacetylase sirtuin-2

SCOPe Domain Sequences for d4y6qb_:

Sequence, based on SEQRES records:

>d4y6qb_ c.31.1.5 (B:) Sirt2 histone deacetylase {Human (Homo sapiens) [TaxId: 9606]}
erlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpyp
eaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleri
agleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivff
geslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekaggggm
dfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaq

Sequence, based on observed residues (ATOM records):

>d4y6qb_ c.31.1.5 (B:) Sirt2 histone deacetylase {Human (Homo sapiens) [TaxId: 9606]}
erlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpyp
eaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleri
agleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivff
geslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagggmd
fdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaq

Timeline for d4y6qb_:

• d4y6qb_ first appeared in SCOPe 2.06
  
• d4y6qb_ appears in SCOPe 2.07