SCOPe 2.07: Domain d4x5ya2: 4x5y A:231-589

Lineage for d4x5ya2 (4x5y A:231-589)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (28 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.8: TPR-like [48452] (10 families)

5. Family a.118.8.1: Tetratricopeptide repeat (TPR) [48453] (21 protein domains)

6. Protein Menin C-terminal domain [310725] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [310974] (27 PDB entries)

8. Domain d4x5ya2: 4x5y A:231-589 [309963]
   Other proteins in same PDB: d4x5ya1
   automated match to d3u85a2
   complexed with 3xw, dms, edo, epe, pg4, so4

Details for d4x5ya2

PDB Entry: 4x5y, 1.59 Å

PDB Description: menin in complex with mi-503

PDB Compounds: (A:) Menin

SCOPe Domain Sequences for d4x5ya2:

Sequence, based on SEQRES records:

>d4x5ya2 a.118.8.1 (A:231-589) Menin C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
drkmevafmvcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleele
ptpgrpdpltlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqd
ynycredeeiykeffevandvipnllkeaaslleagsqgsalqdpecfahllrfydgick
weegsptpvlhvgwatflvqslgrfegqvrqkvrivsvpapaaspppegpvltfqsekmk
gmkellvatkinssaiklqltaqsqvqmkk

Sequence, based on observed residues (ATOM records):

>d4x5ya2 a.118.8.1 (A:231-589) Menin C-terminal domain {Human (Homo sapiens) [TaxId: 9606]}
drkmevafmvcainpsidlhtdslellqlqqkllwllydlghlerypmalgnladleele
ptpgrpdpltlyhkgiasaktyyrdehiypymylagyhcrnrnvrealqawadtatviqd
ynycredeeiykeffevandvipnllkeaaslleagsqgsalqdpecfahllrfydgick
weegsptpvlhvgwatflvqslgrfegqvrqkvrivsvpvltfqsekmkgmkellvatki
nssaiklqltaqsqvqmkk

Timeline for d4x5ya2:

• d4x5ya2 first appeared in SCOPe 2.06