SCOPe 2.08: Domain d4wxra2: 4wxr A:326-627

Lineage for d4wxra2 (4wxr A:326-627)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.14: RNA helicase [52724] (7 proteins)
   duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension

6. Protein automated matches [226986] (8 species)
   not a true protein

7. Species Hepatitis C virus [TaxId:11103] [311460] (2 PDB entries)

8. Domain d4wxra2: 4wxr A:326-627 [309922]
   Other proteins in same PDB: d4wxra1, d4wxrb1
   automated match to d4oksb2
   complexed with 3vz

Details for d4wxra2

PDB Entry: 4wxr, 2.42 Å

PDB Description: x-ray crystal structure of ns3 helicase from hcv with a bound inhibitor at 2.42 a resolution

PDB Compounds: (A:) ns3

SCOPe Domain Sequences for d4wxra2:

Sequence, based on SEQRES records:

>d4wxra2 c.37.1.14 (A:326-627) automated matches {Hepatitis C virus [TaxId: 11103]}
pgsvtvshpnieevalsttgeipfygkaiplevikggrhlifchskkkcdelaaklvalg
inavayyrgldvsviptsgdvvvvstdalmtgftgdfdsvidcntcvtqtvdfsldptft
ietttlpqdavsrtqrrgrtgrgkpgiyrfvapgerpsgmfdssvlcecydagcawyelt
paettvrlraymntpglpvcqdhlefwegvftglthidahflsqtkqsgenfpylvayqa
tvcaraqapppswdqmwkclirlkptlhgptpllyrlgavqnevtlthpitkyimtcmsa
dl

Sequence, based on observed residues (ATOM records):

>d4wxra2 c.37.1.14 (A:326-627) automated matches {Hepatitis C virus [TaxId: 11103]}
pgsvtvshpnieevalsttgeipfygkaiplevikggrhlifchskkkcdelaaklvalg
inavayyrgldvsviptsgdvvvvstdatgdfdsvidcntcvtqtvdfsldptftiettt
lpqdavsrtqrrgrtgrgkpgiyrfvapgerpsgmfdssvlcecydagcawyeltpaett
vrlraymntpglpvcqdhlefwegvftglthidahflsqtkqsgenfpylvayqatvcar
aqapppswdqmwkclirlkptlhgptpllyrlgavqnevtlthpitkyimtcmsadl

Timeline for d4wxra2:

• d4wxra2 first appeared in SCOPe 2.06
  
• d4wxra2 appears in SCOPe 2.07