SCOPe 2.06: Domain d4rj6a_: 4rj6 A:

Lineage for d4rj6a_ (4rj6 A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (90 PDB entries)
   Uniprot P00533 702-1018

8. Domain d4rj6a_: 4rj6 A: [309459]
   automated match to d3ikaa_
   complexed with 3r0, so4

Details for d4rj6a_

PDB Entry: 4rj6, 2.7 Å

PDB Description: EGFR kinase (T790M/L858R) with inhibitor compound 4

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d4rj6a_:

Sequence, based on SEQRES records:

>d4rj6a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records):

>d4rj6a_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaiketspkankeil
deayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvq
iakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgraklvpikwmalesilhriythq
sdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmid
adsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfydmddvvdadeyli

Timeline for d4rj6a_:

• d4rj6a_ is new in SCOPe 2.06-stable
  
• d4rj6a_ appears in SCOPe 2.07
  
• d4rj6a_ appears in the current release, SCOPe 2.08