SCOPe 2.07: Domain d4reza2: 4rez A:1543-1803

Lineage for d4reza2 (4rez A:1543-1803)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
   consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn

4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families)
   the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

5. Family d.3.1.23: Papain-like viral protease catalytic domain [310648] (2 protein domains)
   C-terminal part of Pfam PF08715

6. Protein Papain-like protease PLpro, catalytic domain [310795] (3 species)

7. Species Human betacoronavirus 2c jordan-n3/2012 [TaxId:1306931] [311427] (5 PDB entries)

8. Domain d4reza2: 4rez A:1543-1803 [309422]
   Other proteins in same PDB: d4reza1
   automated match to d4p16a2
   complexed with pgo, zn

Details for d4reza2

PDB Entry: 4rez, 2.8 Å

PDB Description: Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease

PDB Compounds: (A:) ORF1ab protein

SCOPe Domain Sequences for d4reza2:

Sequence, based on SEQRES records:

>d4reza2 d.3.1.23 (A:1543-1803) Papain-like protease PLpro, catalytic domain {Human betacoronavirus 2c jordan-n3/2012 [TaxId: 1306931]}
adetkalkelygpvdptflhrfyslkaavhgwkmvvcdkvrslklsdnncylnavimtld
llkdikfvipalqhafmkhkggdstdfialimaygnctfgapddasrllhtvlakaelcc
sarmvwrewcnvcgikdvvlqglkaccyvgvqtvedlrarmtyvcqcggerhrqlvehtt
pwlllsgtpneklvttstapdfvafnvfqgietavghyvharlkgglilkfdsgtvskts
dwkckvtdvlfpgqkyssdcn

Sequence, based on observed residues (ATOM records):

>d4reza2 d.3.1.23 (A:1543-1803) Papain-like protease PLpro, catalytic domain {Human betacoronavirus 2c jordan-n3/2012 [TaxId: 1306931]}
adetkalkelygpvdptflhrfyslkaavhgwkmvvcdkvrslklsdnncylnavimtld
llkdikfvipalqhafmkhkggdstdfialimaygnctfgapddasrllhtvlakaelcc
sarmvwrewcnvcgikdvvlqglkaccyvgvqtvedlrarmtyvcqcggerhrqlvehtt
pwlllsgtpneklvttapdfvafnvfqgghyvharlklilkfdsgtvsktsdwkckvtdv
lfpgqkyssdcn

Timeline for d4reza2:

• d4reza2 first appeared in SCOPe 2.06